Tier List based on how much FUN each challenge is. NOT BASED ON DIFFICULTY. Pretty subjektive obviously. In the comments you will find a comment that titles every challenge in list order
the binding of isaac rebirth - What's with the crossed out trophy icon? - Arqade
I cannot unlock challenge #4 Darkness Falls (No Repentance spoilers) : r/bindingofisaac
Afterbirth+ Custom Challenge Launcher - Modding of Isaac
Top 10 Binding Of Isaac Rebirth Unique Challenges | Geeky Matters
the binding of isaac rebirth - Challenge run or normal run? - Arqade
Binding of Isaac: Rebirth: 5 Tips to Improve and Initial Impressions | Particlebit